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In the ever-evolving landscape of mental health treatment, individuals are increasingly exploring unconventional paths to healing. One such path gaining attention is the transition from traditional antidepressant medications to the realm of psychedelics. This transition marks a significant shift, both historically and scientifically, in the way we approach mental health challenges. In this article, we’ll delve into the historical roots, the resurgence of research, and the potential benefits and considerations of transitioning from antidepressants to psychedelics.

A Brief History of Psychedelics

The story of psychedelics in the last half-century is one of twists, turns, and reawakening. In the mid-20th century, these substances burst onto the scene with promise and excitement. Pioneers like Albert Hofmann and Timothy Leary brought them into the public consciousness, leading to widespread interest and research. LSD, psilocybin mushrooms, and other substances were studied for their potential in therapy, creative enhancement, and even spiritual exploration.

However, the era of promise was met with some challenges. Concerns about potential misuse, legal complexities, and societal shifts led to a temporary decline in research and public acceptance. Governments around the world categorized psychedelics as controlled substances, temporarily limiting their exploration within the scientific and medical communities. Yet, the legacy of these substances persisted, and their potential for positive impact endured even during these quieter years.

Antidepressants to Psychedelics – Guide to Macrodosing

In our exploration of transitioning from antidepressants to psychedelics, the concept of macrodosing emerges as a powerful avenue for those seeking profound mental and emotional transformation. Guided by the groundbreaking research of Robin Carhart-Harris, macrodosing offers a unique opportunity to delve deep into altered states of consciousness for therapeutic purposes. In this section, we provide a comprehensive guide to macrodosing, drawing on the insights provided by Carhart-Harris’s research, to ensure a safe, informed, and transformative experience.

Understanding Macrodosing: A Journey into Altered States

Macrodosing involves consuming larger doses of psychedelics to induce intense and transformative altered states of consciousness. This approach is distinct from microdosing, which employs smaller doses for subtle effects. Macrodosing is often undertaken in therapeutic settings and controlled environments to explore profound insights, emotional processing, and personal growth. Carhart-Harris’s research has shed light on the potential therapeutic benefits of macrodosing, offering a roadmap for individuals seeking a deeper connection with their inner selves.

Robin Carhart-Harris’s Research: Insights into Macrodosing

Carhart-Harris’s pioneering studies using neuroimaging techniques have provided invaluable insights into the effects of psychedelics on the brain during macrodosing experiences. His work highlights that macrodosing can lead to increased neural plasticity—a state where the brain’s pathways become more flexible and amenable to change. This plasticity is linked to the potential therapeutic effects of macrodosing, facilitating the exploration and restructuring of thought patterns, emotions, and traumas.

Moreover, Carhart-Harris’s research has revealed that macrodosing can temporarily suppress the default mode network (DMN)—the network associated with self-referential thoughts. This suppression can lead to a dissolution of the ego, offering a unique opportunity for introspection and a fresh perspective on one’s life and experiences.

Preparing for a Macrodosing Journey

We recommend trying out our “healing package” to start off your macrodosing journey.

Embarking on a macrodosing journey requires careful planning and preparation. Drawing from Carhart-Harris’s research, here are key steps to consider:

  1. Education: Educate yourself about the substance you plan to use, its effects, and potential risks. Carhart-Harris’s studies emphasize the need for understanding the substance’s impact on brain function.
  2. Setting: Choose a safe, comfortable, and supportive environment for your macrodosing experience. This setting can significantly influence the quality of your journey.
  3. Guidance: Whenever possible, seek professional guidance from therapists, facilitators experienced in psychedelic-assisted therapy or experienced trip sitters. Carhart-Harris’s research underscores the importance of having a trained professional to guide you.
  4. Mindset: Approach the experience with an open mind and a positive mindset. Carhart-Harris’s findings suggest that psychological preparedness can influence the outcomes of the journey.
  5. Dosage: Determine the appropriate dosage based on your goals and the substance’s potency. Carhart-Harris’s research can inform your decision, but individual responses vary.

The Journey Itself: Navigating the Experience

During the macrodosing experience, embrace the insights provided by Carhart-Harris’s research:

  1. Introspection: Take advantage of the altered state to explore your thoughts, emotions, and memories. Carhart-Harris’s work suggests that the brain’s flexibility during macrodosing can facilitate deep introspection.
  2. Letting Go: Allow the experience to unfold without resistance. Carhart-Harris’s findings on DMN suppression highlight the potential for ego dissolution, enabling fresh perspectives.

After the Journey: Integration and Reflection

Carhart-Harris’s research underlines the importance of integration—bringing insights from the journey into your daily life. Reflect on the experience, journal your thoughts, and consider how the insights gained can positively impact your mental well-being.

Antidepressants to Psychedelics – Guide to Microdosing

As we venture into the realm of transitioning from antidepressants to psychedelics, the practice of microdosing emerges as a fascinating avenue for those seeking subtle shifts in mental well-being. Guided by the pioneering research of Robin Carhart-Harris, microdosing offers a unique pathway to harness the therapeutic potential of psychedelics without the intensity of a full psychedelic experience. In this section, we present a comprehensive guide to microdosing, drawing from the insights provided by Carhart-Harris’s research, to help you embark on a safe, mindful, and transformative journey.

Understanding Microdosing: A Subtle Approach to Transformation

Microdosing involves taking minimal amounts of psychedelics to induce subtle cognitive enhancements and emotional shifts. Unlike macrodosing, which aims for profound altered states, microdosing is characterized by its sub-perceptual effects. Robin Carhart-Harris’s research has unveiled potential benefits associated with microdosing, making it an intriguing option for those seeking to optimize their mental well-being.

Leveraging Robin Carhart-Harris’s Research: Unveiling Microdosing Insights

Carhart-Harris’s pioneering studies have illuminated the brain’s response to psychedelics, including the sub-perceptual effects of microdosing. His research suggests that microdosing may modulate neural pathways, influencing mood, creativity, and overall mental state. By understanding these insights, you can approach microdosing with a science-backed perspective.

Preparing for a Microdosing Journey

Embarking on a microdosing journey requires thoughtful preparation. Here are key steps influenced by Carhart-Harris’s research:

  1. Education: Familiarize yourself with the substance, dosing protocols, and potential effects. Carhart-Harris’s studies provide a foundation for understanding the implications of microdosing.
  2. Setting an Intention: Clarify your goals for microdosing—whether it’s enhanced focus, creativity, or mood regulation. Carhart-Harris’s research underscores the importance of intention-setting.
  3. Dosing Protocol: Follow a structured dosing schedule, often involving dosing every few days. Carhart-Harris’s research encourages consistency to observe the cumulative effects.

Such a dosing protocol can be observed on our microdosing product pages, see here:

Transitioning yourself off anti-depressants

We are not Doctors, and this information should not be taken as certified medical information. Please do your own research.

  1. Always speak with your Doctor before discontinuing any medication, this is obvious but most people just think “My doctor would never support psychedelics” this may be true but still bring it up, if your doctor is completely closed minded you may need to take it into your own hands. Doctors learn from textbooks that are usually relatively outdated, so unless they’ve done their own research they’ll probably not recommend it.
  2. Gradually taper off the medication, after two weeks of completely ceasing consumption you can then start you micro dosing journey.
  3. Educate yourself: Do LOTS of research, watch youtube videos, read papers, know the differences between all Psychedelics and the relationship they have with our brain. Learn as much as you can, and become an expert.
  4. Anecdotal Experiences: Look up anecdotes of others who have also transitioned from anti-depressants to Psychedelics. Reddit, and YouTube are examples of where you can find people reporting their experiences.
  5. Explore different protocols. We outline one for Microdosing Psilocybin, and Microdosing LSD.

Microdosing Psilocybin: 4 days on, 3 days off.

Microdosing LSD: 15ug every 3 days.

We encourage all to experiment with their own protocol after 2 weeks of following our recommended one.

We provide a guide pamphlet with every order, please keep that with you and follow it.

The Microdosing Experience: Navigating Subtle Shifts

During the microdosing experience, draw from Carhart-Harris’s insights:

  1. Enhanced Creativity: Embrace your newfound creativity and heightened cognitive flexibility. Carhart-Harris’s research suggests that microdosing can enhance creative problem-solving.
  2. Emotional Resilience: Observe your emotional state and its potential upliftment. Carhart-Harris’s findings point to microdosing’s role in mood modulation.

After the Microdosing Phase: Integration and Reflection

Following the microdosing phase, integrate your experiences into daily life. Carhart-Harris’s research emphasizes reflection and integration to fully benefit from the insights gained.

Resources and Further Reading: Delving Deeper into the Journey

As we conclude our exploration of transitioning from antidepressants to psychedelics, the quest for knowledge and understanding continues. For those who seek to delve deeper into this transformative journey, here is a curated list of recommended resources and further reading:


  • “How to Change Your Mind” by Michael Pollan
  • “The Psychedelic Explorer’s Guide” by James Fadiman
  • “The Science of Psychedelics” by Robin Carhart-Harris

Websites and Organizations:

  • Multidisciplinary Association for Psychedelic Studies (MAPS): A leading organization focused on psychedelic research, therapy, and education.
  • Beckley Foundation: A research-focused organization dedicated to advancing the understanding of psychedelics and their potential benefits.
  • Heffter Research Institute: A nonprofit organization supporting scientific research on the therapeutic uses of psychedelics.

This comprehensive guide aims to provide readers with a well-rounded understanding of transitioning from antidepressants to psychedelics, offering insights, considerations, and practical guidance for a transformative and informed journey towards improved mental well-being.

Huberman Lab Podcast with Robin Carhart-Harris –

Trial of Psilocybin versus Escitalopram for Depression –

Increased global integration in the brain after psilocybin therapy for depression –

Psilocybin with psychological support for treatment-resistant depression: six-month follow-up –


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